Phenidone

Research use only, not for human use.

Phenidone is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.

Phenidone is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat.(In Vitro):Western blot analysis showed that phenidone significantly inhibited the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with EAE.(In Vivo):Lipoxygenase inhibitor phenidone markedly attenuates angiotensin II (AII) induced vascular contractility. Phenidone was also shown to inhibit the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat.

Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE).

Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat.

1-phenyl-3-pyrazolidinone

Immunology/Inflammation

Lipoxygenase

——

——

——

92-43-3

162.192

C9H10N2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (616.56 mM)

OC1=NN(CC1)c1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years