2-Fucosyllactose

Research use only, not for human use.

2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk.

2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines.

2'-Fucosyllactose (2'-FL; 0-12 mg/mL; 48 h) suppress cell-associated CD14 expression and to attenuate LPS (100 μg/mL) stimulated IL-8 secretion in T84 cells.2'-Fucosyllactose (2 mg/mL; 48 h; T84 and HCT8 cells) ameliorates inflammation induced by bacterial invasion. 2'-Fucosyllactose inhibits ETEC invasion and attenuated the consequent IL-8 secretion.2'-Fucosyllactose (2 mg/mL; 48 h; T84 and HCT8 cells) induces macrophage migration inhibitory factor signal pathways that suppress inflammation. Western Blot Analysis Cell Line:T84 cells Concentration:0, 2, and 4 mg/mL Incubation Time:48 hours Result:Suppressed CD14 mRNA and reduced cell-associated CD14 protein expression.Western Blot Analysis Cell Line:T84 and HCT8 cells T84 and HCT8 cells Concentration:2 mg/mL Incubation Time:48 hours Result:Suppressed CD14 mRNA and reduced cell-associated CD14 protein expression.Inhibited CD14 and NF-κB induction.Induced iκB and SOCS2 expression and STAT3 phosphorylation.

2'-Fucosyllactose (2'-FL; 100 mg (200 μL); i.g.; daily, for 4 d; C57BL/6 mice with AIEC infection) inhibits AIEC infection and inflammation in vivo. Animal Model:C57BL/6 mice (8 weeks) with AIEC (uropathogenic E. coli, and adherent-invasive E. coli) infection Dosage:100 mg (200 μL)Administration:Oral gavage; daily, for 4 days Result:Had colons lengths were closer to normal.Inhibited the colonisation of the colonic mucosa by O83-positive bacteria.Decreased CD14 expression, CD14 mRNA levels, IL-6, IL-17 and TNF-α levels in colonic.

2'-FL

Apoptosis

TNF

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41263-94-9

488.44

C18H32O15

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (102.37 mM)

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(-20℃)

With Ice Pack

≥ 2 years