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(Rac)-Benpyrine
CAS No. 1333714-43-4
(Rac)-Benpyrine( —— )
Catalog No. M22543 CAS No. 1333714-43-4
(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 107 | In Stock |
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| 2MG | 56 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 155 | In Stock |
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| 25MG | 312 | In Stock |
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| 50MG | 458 | In Stock |
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| 100MG | 640 | In Stock |
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| 200MG | 905 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product Name(Rac)-Benpyrine
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NoteResearch use only, not for human use.
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Brief Description(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
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Description(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
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In Vitro(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages.
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In Vivo(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction. Animal Model:Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant Dosage:25 mg/kg, 50 mg/kg Administration:Oral gavage; daily; for 3 weeks Result:The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.
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Synonyms——
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PathwayApoptosis
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TargetTNF
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RecptorTNF-α
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Research Area——
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Indication——
Chemical Information
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CAS Number1333714-43-4
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Formula Weight308.34
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Molecular FormulaC16H16N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (32.43 mM)
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SMILESO=C1CC(CN1Cc1ccccc1)Nc1ncnc2[nH]cnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Lenalidomide
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