Cart
sales@molnova.com
CCI 007
CAS No. 939228-52-1
CCI 007( —— )
Catalog No. M24990 CAS No. 939228-52-1
CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
|
| 5MG | 65 | In Stock |
|
| 10MG | 107 | In Stock |
|
| 25MG | 217 | In Stock |
|
| 50MG | 352 | In Stock |
|
| 100MG | 569 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCCI 007
-
NoteResearch use only, not for human use.
-
Brief DescriptionCCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
-
DescriptionCCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
-
In VitroCCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia.Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2.Resistance to CCI-007 can occur by upregulation of MLL target gene expression. :Cell Viability Assay Cell Line:PER-485, MOLM-13, MV4;11 cells.Concentration:5 μM.Incubation Time:24 h.Result:Induced apoptosis.
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetHistone Demethylase
-
RecptorMLL-r
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number939228-52-1
-
Formula Weight336.36
-
Molecular FormulaC15H16N2O5S
-
Purity>98% (HPLC)
-
SolubilityDMSO:10 mM
-
SMILESO=C(OCC)COC(C=CC(C=C1SC(N)=NC1=O)=C2)=C2OC
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Somers K , Chudakova D A , Middlemiss S , et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements[J]. Oncotarget, 2016, 7(29):46067-46087.
molnova catalog
related products
-
M?89
M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.?M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin.
-
GSK J5
GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-dependent manner.
-
KDM4C-IN-1
KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.
