SETDB1-TTD-IN-1( —— )

Catalog No. M28873 CAS No. 2755823-12-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SETDB1-TTD-IN-1
Note

Research use only, not for human use.
Brief Description

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.
Description

SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.(In Vitro):SETDB1-TTD-IN-1 (2.5-40 μM) efficiently and dose-dependently stabilizes the SETDB1-TTD protein in HEK293T cells. SETDB1-TTD-IN-1 (2.5-40 μM; 24 h) significantly affected the expression of 72 genes in human acute monocytic leukemia THP-1 cells. SETDB1-TTD-IN-1 shows some activity for 53BP1 and JMJD2A, with Kds of 4.3 μM and 86 μM, respectively. SETDB1-TTD-IN-1 does not show activity against 14 of the 16 tested tudor domains (Kd>100 μM).
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Fusion protein|RSV
Research Area

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Indication

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CAS Number

2755823-12-0
Formula Weight

469.58
Molecular Formula

C28H31N5O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (266.20 mM)
SMILES

CN1C[C@H](C[C@H](C1)NC2=NC3=C(NC=C3)C(N2CC=C)=O)C4=CC=C(C=C4)OCC5=CC=CC=C5
Chemical Name

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1.Roymans D, et al. Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat Commun. 2017 Aug 1;8(1):167.

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