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KDM4C-IN-1

CAS No. 52348-60-4

KDM4C-IN-1( —— )

Catalog No. M35451 CAS No. 52348-60-4

KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.

Purity : >98% (HPLC)

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Biological Information

Product Name

KDM4C-IN-1
Note

Research use only, not for human use.
Brief Description

KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.
Description

KDM4C-IN-1 (Compound 4d) is a potent KDM4C inhibitor with an IC50 of 8 nM. KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells with IC50s of 0.8 μM and 1.1 μM, respectively.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

——
Indication

——

Chemical Information

CAS Number

52348-60-4
Formula Weight

298.3
Molecular Formula

C15H14N4O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 3 mg/mL (10.02 mM )
SMILES

COc1ccc(cc1)-c1nn(C)c2nc(=O)n(C)c(=O)c2n1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Vatroslav Letfus, et al. Rational design, synthesis and biological profiling of new KDM4C inhibitors. Bioorg Med Chem. 2020 Jan 1;28(1):115128. ?

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