Purpurogallin

Research use only, not for human use.

Purpurogallin is a naturally phenol extracted from the plants of Quercus spp.

Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 μM). Purpurogallin also has antioxidant and anti-inflammatory effects.

Purpurogallin (50 or 100 μM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.Purpurogallin (100 μM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells. RT-PCR Cell Line:BV2 murine microglial cells Concentration:50 or 100 μM Incubation Time:7 or 25 hours Result:Attenuated the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression.Western Blot Analysis Cell Line:BV2 murine microglial cells Concentration:100 μM Incubation Time:75 minutes, 90 minutes, 120 minutes Result:Suppressed the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways.

Purpurogallin (100-400?μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression. Animal Model:Fifty-four male Sprague-Dawley rats (250-350?g) with subarachnoid hemorrhage (SAH) Dosage:100?μg/kg, 200?μg/kg, 400?μg/kg Administration: Intraperitoneal injection; for 48 or 72 hours Result:Dose-dependently reduced HMGB1 protein expression. High dose reduced TNF-α and HMGB1 mRNA levels.

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Metabolic Enzyme/Protease

Xanthine Oxidase (XAO)

xanthine oxidase

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569-77-7

220.18

C11H8O5

>98% (HPLC)

DMSO:125 mg/mL (567.72 mM; Need ultrasonic)

O=C1C(O)=CC=CC2=CC(O)=C(O)C(O)=C21

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(-20℃)

With Ice Pack

≥ 2 years