Norathyriol

Research use only, not for human use.

Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.

Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.

Norathyriol (1-25 μM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest.Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cellsCell Growth Assay WB Cell Viability Assay Cell Line:Mouse skin epidermal JB6 P+ cells Concentration:0, 1, 10, or 25 μM Incubation Time:24 or 72 hours Result:Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death. Western Blot Analysis Cell Line:JB6 P+ cells Concentration:0, 1, 10, or 25 μM Incubation Time:2 hours Result:Inhibited UVB-induced phosphorylation of ERKs and p90RSK.

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety. Norathyriol (0.92, 1.85 and 3.7?mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively. Animal Model:Adult Kunming mice weighing 18-22?g Dosage:0.92, 1.85 and 3.7?mg/kg Administration:Administered intragastrically; twice daily for five times Result:The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

——

Cytoskeleton/Cell Adhesion Molecules

Akt

Akt|AMPK|AP-1

——

——

3542-72-1

260.2

C13H8O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (384.32 mM)

C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O

——

(-20℃)

With Ice Pack

≥ 2 years