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K-80003
CAS No. 1292821-90-9
K-80003( —— )
Catalog No. M32977 CAS No. 1292821-90-9
K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 96 | In Stock |
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| 25MG | 169 | In Stock |
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| 50MG | 253 | In Stock |
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| 100MG | 372 | In Stock |
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| 200MG | 529 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameK-80003
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NoteResearch use only, not for human use.
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Brief DescriptionK-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth.
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DescriptionK-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.
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In VitroWhen MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.
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In VivoK-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity.
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorRAR/RXR? | Akt
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Research Area——
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Indication——
Chemical Information
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CAS Number1292821-90-9
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Formula Weight336.4
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Molecular FormulaC22H21FO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 30 mg/mL (89.18 mM; Ultrasonic )
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SMILESCC(C)c1ccc(\C=C2\C(C)=C(CC(O)=O)c3cc(F)ccc23)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73.?
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