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Aurora Kinase Inhibitor II

CAS No. 331770-21-9

Aurora Kinase Inhibitor II( IUN-70219 )

Catalog No. M24269 CAS No. 331770-21-9

Aurora Kinase Inhibitor II is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 154 In Stock
5MG 141 In Stock
10MG 212 In Stock
25MG 381 In Stock
50MG 551 In Stock
100MG 815 In Stock
200MG 1097 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Aurora Kinase Inhibitor II
  • Note
    Research use only, not for human use.
  • Brief Description
    Aurora Kinase Inhibitor II is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
  • Description
    Aurora Kinase Inhibitor II is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
  • In Vitro
    Aurora kinase inhibitor-2 (Compound 1) shows excellent levels of Aurora A enzyme inhibition and is also effective in an MCF7 cellular anti-proliferative assay (IC50 value of 1.25 μM).
  • In Vivo
    ——
  • Synonyms
    IUN-70219
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Aurora Kinase
  • Recptor
    Aurora A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    331770-21-9
  • Formula Weight
    400.43
  • Molecular Formula
    C23H20N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    O=C(NC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1)C4=CC=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Heron N M , Anderson M , Blowers D P , et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16(5):1320-1323.
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