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Aurora Kinase Inhibitor II
CAS No. 331770-21-9
Aurora Kinase Inhibitor II( IUN-70219 )
Catalog No. M24269 CAS No. 331770-21-9
Aurora Kinase Inhibitor II is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 154 | In Stock |
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| 5MG | 141 | In Stock |
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| 10MG | 212 | In Stock |
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| 25MG | 381 | In Stock |
|
| 50MG | 551 | In Stock |
|
| 100MG | 815 | In Stock |
|
| 200MG | 1097 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAurora Kinase Inhibitor II
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NoteResearch use only, not for human use.
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Brief DescriptionAurora Kinase Inhibitor II is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
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DescriptionAurora Kinase Inhibitor II is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
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In VitroAurora kinase inhibitor-2 (Compound 1) shows excellent levels of Aurora A enzyme inhibition and is also effective in an MCF7 cellular anti-proliferative assay (IC50 value of 1.25 μM).
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In Vivo——
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SynonymsIUN-70219
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PathwayCell Cycle/DNA Damage
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TargetAurora Kinase
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RecptorAurora A
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Research Area——
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Indication——
Chemical Information
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CAS Number331770-21-9
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Formula Weight400.43
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Molecular FormulaC23H20N4O3
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESO=C(NC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1)C4=CC=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Heron N M , Anderson M , Blowers D P , et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16(5):1320-1323.
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