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ENMD-2076 tartrate

CAS No. 1291074-87-7

ENMD-2076 tartrate( ENMD 2076 | ENMD2076 )

Catalog No. M11180 CAS No. 1291074-87-7

A multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ENMD-2076 tartrate
  • Note
    Research use only, not for human use.
  • Brief Description
    A multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2.
  • Description
    A multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2; also inhibits Aurora B, c-Kit, FGFR1 (IC50=100-350 nM); orally bioactive.Liver CancerPhase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ENMD 2076 | ENMD2076
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Aurora Kinase
  • Recptor
    FLT3 , RET , Aurora A , VEGFR3/FLT4 , Src
  • Research Area
    Cancer
  • Indication
    Liver Cancer

Chemical Information

  • CAS Number
    1291074-87-7
  • Formula Weight
    525.5569
  • Molecular Formula
    C25H31N7O6
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=CC(NC2=NC(/C=C/C3=CC=CC=C3)=NC(N4CCN(C)CC4)=C2)=NN1.OC(C(C(O)=O)O)C(O)=O
  • Chemical Name
    4-Pyrimidinamine, 6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(1E)-2-phenylethenyl]- Tartrate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tentler JJ, et al. Clin Cancer Res. 2010 Jun 1;16(11):2989-98. 2. Matulonis UA, et al. Eur J Cancer. 2013 Jan;49(1):121-31. 3. Fletcher GC, et al. Mol Cancer Ther. 2011 Jan;10(1):126-37.
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