BPR1K653( BPR1K 653 )

Catalog No. M10668 CAS No. 1192754-06-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BPR1K653
Note

Research use only, not for human use.
Brief Description

BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively.
Description

BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively; exhibits less potency (IC50>10 uM) in inhibiting the activity of ALK, CHK1, cMET, EGFR, FLT3, VEGFR1 and VEGFR2; induces concentration-dependent decrease in phosphor-Aurora-A, -B and -C kinase in HCT116 cells, inhibits the proliferation of multiple human cancer cell lines regardless of their tissue origins and p53 status (IC50s<0.5 uM); shows equal potency in inhibiting the growth of the multiple-drug resistance protein (MDR1) -expressing cancer cells; also is effective toward MDR1-expressing tumor xenograft.
In Vitro

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In Vivo

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Synonyms

BPR1K 653
Pathway

Cell Cycle/DNA Damage
Target

Aurora Kinase
Recptor

Aurora Kinase
Research Area

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Indication

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CAS Number

1192754-06-5
Formula Weight

541.052
Molecular Formula

C30H29ClN6O2
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(NC1=CC=CC=C1CN(C)C)NC2=CC=C(CCNC3=C4C(OC(C5=CC=CC=C5)=C4Cl)=NC=N3)C=C2
Chemical Name

1-(4-(2-((5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-(2-((dimethylamino)methyl)phenyl)urea

1. Cheung CH, et al. PLoS One. 2011;6(8):e23485.

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