Cart
sales@molnova.com
BPR1K653
CAS No. 1192754-06-5
BPR1K653( BPR1K 653 )
Catalog No. M10668 CAS No. 1192754-06-5
BPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBPR1K653
-
NoteResearch use only, not for human use.
-
Brief DescriptionBPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively.
-
DescriptionBPR1K653 is a novel potent Aurora kinase inhibitor that inhibits Aurora-A and Aurora-B with IC50 of 24 nM and 45 nM, respectively; exhibits less potency (IC50>10 uM) in inhibiting the activity of ALK, CHK1, cMET, EGFR, FLT3, VEGFR1 and VEGFR2; induces concentration-dependent decrease in phosphor-Aurora-A, -B and -C kinase in HCT116 cells, inhibits the proliferation of multiple human cancer cell lines regardless of their tissue origins and p53 status (IC50s<0.5 uM); shows equal potency in inhibiting the growth of the multiple-drug resistance protein (MDR1) -expressing cancer cells; also is effective toward MDR1-expressing tumor xenograft.
-
In Vitro——
-
In Vivo——
-
SynonymsBPR1K 653
-
PathwayCell Cycle/DNA Damage
-
TargetAurora Kinase
-
RecptorAurora Kinase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1192754-06-5
-
Formula Weight541.052
-
Molecular FormulaC30H29ClN6O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(NC1=CC=CC=C1CN(C)C)NC2=CC=C(CCNC3=C4C(OC(C5=CC=CC=C5)=C4Cl)=NC=N3)C=C2
-
Chemical Name1-(4-(2-((5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-(2-((dimethylamino)methyl)phenyl)urea
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Cheung CH, et al. PLoS One. 2011;6(8):e23485.
molnova catalog
related products
-
Phthalazinone pyrazo...
Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity.
-
AS 703569
Cenisertib (AS 703569;R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM).
-
CD532
CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directly interact with AURKA and induce global conformational transformation. CD532 can be used to study cancer.
