Endovion

Research use only, not for human use.

Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.

Endovion is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.

Western Blot Analysis Cell Line:Wild-type, resistant, and transiently transfected A2780 cells.Concentration:10-100 μM.Incubation Time:18 or 4.5 h.Result:Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells.Resulted in an increased LRRC8A protein expression.Significantly reduceed p53 and p21Waf1/Cip1 protein level in A2780WT cells.Cell Proliferation Assay Cell Line:Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines.Concentration:10 μM.Incubation Time:24 h.Result:Resulted in the most pronounced inhibition in all cell lines with 77?±?26 % in Capan-1, 67?±?9 % in AsPC-1, and 54?±?8 % in BxPC-3 cells at +67 mV.

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NS3728

Membrane Transporter/Ion Channel

Chloride Channel

Chloride channel|VRAC/VSOAC

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265646-85-3

495.18

C16H9BrF6N6O

>98% (HPLC)

DMSO:120 mg/mL (242.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)

O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Nc(cc(cc1)Br)c1-c1n[nH]nn1

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(-20℃)

With Ice Pack

≥ 2 years