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BI-2852
CAS No. 2375482-51-0
BI-2852( —— )
Catalog No. M24089 CAS No. 2375482-51-0
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 314 | In Stock |
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| 5MG | 276 | In Stock |
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| 10MG | 410 | In Stock |
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| 25MG | 679 | In Stock |
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| 50MG | 918 | In Stock |
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| 100MG | 1265 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBI-2852
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NoteResearch use only, not for human use.
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Brief DescriptionBI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity.
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DescriptionBI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorKRAS G12C
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Research Area——
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Indication——
Chemical Information
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CAS Number2375482-51-0
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Formula Weight516.59
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Molecular FormulaC31H28N6O2
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Purity>98% (HPLC)
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SolubilityDMSO:55 mg/mL (106.47 mM; Need ultrasonic)
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SMILESCn1cnc(Cn(cc2)c3c2ccc(CNCc2c([C@H](c4c5ccc(O)c4)NC5=O)c(cccc4)c4[nH]2)c3)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kessler D, et al. Drugging an undruggable pocket on KRAS. Proc Natl Acad Sci U S A. 2019 Aug 6; 116(32):15823-15829.
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