Irisolidone( —— )

Catalog No. M24066 CAS No. 2345-17-7

Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Irisolidone
Note

Research use only, not for human use.
Brief Description

Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
Description

Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
In Vitro

Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells.Irisolidone can inhibit endothelial cell proliferation.
In Vivo

——
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

Chloride Channel
Recptor

VRAC|IL Receptor|NF-Κb
Research Area

——
Indication

——

Chemical Information

CAS Number

2345-17-7
Formula Weight

314.29
Molecular Formula

C17H14O6
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(O)=C(OC)C(O)=C13
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation.Pflugers Arch. 2018 Jun 30.

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