FASN-IN-3( —— )

Catalog No. M23946 CAS No. 2097262-60-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

FASN-IN-3
Note

Research use only, not for human use.
Brief Description

FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
Description

FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).
In Vitro

Human PBMC and monocytes in cell cultures are stimulated with lipopolysaccharide (LPS), a Toll 4 receptor agonist, or lipoteichoic acid (LTA), a Toll 2 receptor agonist. Stimulation with either LPS or LTA plus DMSO, the solvent for FASN-IN-3 (Compound 242A), results in secretion of IL-1 beta. FASN inhibitor 1 treatment of PBMC, which is a mixed population of mononuclear cells including both lymphocytes and monocytes, reduces the level of IL-1 beta resulting from either LPS or LTA stimulation. For monocytes, FASN-IN-3 treatment reduces the level of IL-1 beta resulting from LTA stimulation whereas there is only a slight reduction after LPS stimulation.
In Vivo

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Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Fatty Acid Synthase
Recptor

FASN
Research Area

——
Indication

——

CAS Number

2097262-60-5
Formula Weight

384.47
Molecular Formula

C24H24N4O
Purity

>98% (HPLC)
Solubility

DMSO:33.33 mg/mL?(86.69 mM;?ultrasonic and warming and heat to 80°C)
SMILES

Cc1n[nH]c(c1C)-c1cc(C(=O)N2CC(C2)c2ccc(cc2)C#N)c(C)cc1C
Chemical Name

——

1.Buckley, Douglas I, et al. HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS. US20170119786A1

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