FASN-IN-3

Research use only, not for human use.

FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).

FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).

Human PBMC and monocytes in cell cultures are stimulated with lipopolysaccharide (LPS), a Toll 4 receptor agonist, or lipoteichoic acid (LTA), a Toll 2 receptor agonist. Stimulation with either LPS or LTA plus DMSO, the solvent for FASN-IN-3 (Compound 242A), results in secretion of IL-1 beta. FASN inhibitor 1 treatment of PBMC, which is a mixed population of mononuclear cells including both lymphocytes and monocytes, reduces the level of IL-1 beta resulting from either LPS or LTA stimulation. For monocytes, FASN-IN-3 treatment reduces the level of IL-1 beta resulting from LTA stimulation whereas there is only a slight reduction after LPS stimulation.

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Metabolic Enzyme/Protease

Fatty Acid Synthase

FASN

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2097262-60-5

384.47

C24H24N4O

>98% (HPLC)

DMSO:33.33 mg/mL?(86.69 mM;?ultrasonic and warming and heat to 80°C)

Cc1n[nH]c(c1C)-c1cc(C(=O)N2CC(C2)c2ccc(cc2)C#N)c(C)cc1C

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(-20℃)

With Ice Pack

≥ 2 years