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Home - Products - Proteasome/Ubiquitin - DUB - USP7-IN-8

USP7-IN-8

CAS No. 2009273-60-1

USP7-IN-8( GNE-6776 )

Catalog No. M23902 CAS No. 2009273-60-1

USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 102 In Stock
5MG 93 In Stock
10MG 150 In Stock
25MG 283 In Stock
50MG 403 In Stock
100MG 551 In Stock
200MG 728 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    USP7-IN-8
  • Note
    Research use only, not for human use.
  • Brief Description
    USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
  • Description
    USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
  • In Vitro
    USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4.
  • In Vivo
    ——
  • Synonyms
    GNE-6776
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    USP7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2009273-60-1
  • Formula Weight
    348.4
  • Molecular Formula
    C20H20N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:80mg/ml(230.08mM; need ultrasonic)
  • SMILES
    CCc(c(-c(cc1)ccc1O)c(N)nc1)c1-c(cc1)cnc1C(NC)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Blake R , Lello P D , Drummond J , et al. USP7 INHIBITOR COMPOUNDS AND METHODS OF USE:, US20160272588[P]. 2016.
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