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TAS6417
CAS No. 1661854-97-2
TAS6417( —— )
Catalog No. M23746 CAS No. 1661854-97-2
TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
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| 2MG | 120 | In Stock |
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| 5MG | 188 | In Stock |
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| 10MG | 312 | In Stock |
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| 25MG | 629 | In Stock |
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| 50MG | 821 | In Stock |
|
| 100MG | 1107 | In Stock |
|
| 200MG | 1516 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTAS6417
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NoteResearch use only, not for human use.
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Brief DescriptionTAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC.
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DescriptionTAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
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In VitroApoptosis Analysis Cell Line:PC-9, H1975, BID007, BID019, BEAS-2B cells.Concentration:0-10 μM.Incubation Time:24-48 h.Result:Led to apoptosis via inhibition of mutant EGFR.
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In VivoAnimal Model:Mice implanted with NCI-H1975 EGFR D770_N771insSVD xenografts.Dosage:50 and 100 mg/kg.Administration:Orally once daily for 14 days.Result:Showed marked tumor growth inhibition with treatment/control (T/C) ratios of 51% and 19%, respectively.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis|EGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number1661854-97-2
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Formula Weight396.44
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Molecular FormulaC23H20N6O
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (315.31 mM)
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SMILESCC1=C[C@@H](CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hasako S, et al. TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. Mol Cancer Ther. 2018 Aug;17(8):1648-1658.
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