HNPMI( —— )

Catalog No. M37340 CAS No. 1980848-48-3

HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, and can promote apoptosis, and can be used for the study of colorectal cancer.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	33	In Stock
5MG	53	In Stock
10MG	88	In Stock
25MG	180	In Stock
50MG	276	In Stock
100MG	454	In Stock
200MG	Get Quote	In Stock
500MG	986	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

HNPMI
Note

Research use only, not for human use.
Brief Description

HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, and can promote apoptosis, and can be used for the study of colorectal cancer.
Description

HNPMI is an inhibitor of EGFR and has cytotoxic effects on tumor cells. HNPMI can downregulate the protein levels of osteopontin, survivin and cathepsin S, leading to apoptosis. HNPMI also regulates BCL-2/BAX and p53 in CRC cell lines to inhibit tumorigenesis.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis | EGFR
Research Area

——
Indication

——

Chemical Information

CAS Number

1980848-48-3
Formula Weight

360.41
Molecular Formula

C22H20N2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=[N+]([O-])C1=CC=C(C(C(N2C3=C(CC2)C=CC=C3)C4=CC=C(C)C=C4)=C1)O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kandhavelu J, et al. A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer. Br J Pharmacol. 2024 Jan;181(1):107-124.?

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