Cart
sales@molnova.com
HNPMI
CAS No. 1980848-48-3
HNPMI( —— )
Catalog No. M37340 CAS No. 1980848-48-3
HNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, and can promote apoptosis, and can be used for the study of colorectal cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | In Stock |
|
| 5MG | 53 | In Stock |
|
| 10MG | 88 | In Stock |
|
| 25MG | 180 | In Stock |
|
| 50MG | 276 | In Stock |
|
| 100MG | 454 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 986 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameHNPMI
-
NoteResearch use only, not for human use.
-
Brief DescriptionHNPMI is an EGFR inhibitor that induces G0/G1 phase arrest of CRC cells in colorectal cancer, regulates enzymes associated with apoptosis, and can promote apoptosis, and can be used for the study of colorectal cancer.
-
DescriptionHNPMI is an inhibitor of EGFR and has cytotoxic effects on tumor cells. HNPMI can downregulate the protein levels of osteopontin, survivin and cathepsin S, leading to apoptosis. HNPMI also regulates BCL-2/BAX and p53 in CRC cell lines to inhibit tumorigenesis.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | EGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1980848-48-3
-
Formula Weight360.41
-
Molecular FormulaC22H20N2O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=[N+]([O-])C1=CC=C(C(C(N2C3=C(CC2)C=CC=C3)C4=CC=C(C)C=C4)=C1)O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kandhavelu J, et al. A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer. Br J Pharmacol. 2024 Jan;181(1):107-124.?
molnova catalog
related products
-
Sulforaphene
Sulforaphene, isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10-4 M.
-
DB2313
DB2313 is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects
-
Geranylgeraniol
Geranylgeraniol is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol protects monocytes against statin-induced cytotoxicity and suppresses the growth of Mycobacterium.
