Cart
sales@molnova.com
JPH203
CAS No. 1037592-40-7
JPH203( KYT-0353 | KYT0353 | KYT 0353 | JPH-203 )
Catalog No. M10188 CAS No. 1037592-40-7
JPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 56 | In Stock |
|
| 5MG | 80 | In Stock |
|
| 10MG | 115 | In Stock |
|
| 25MG | 192 | In Stock |
|
| 50MG | 338 | In Stock |
|
| 100MG | 434 | In Stock |
|
| 200MG | 641 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameJPH203
-
NoteResearch use only, not for human use.
-
Brief DescriptionJPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition).
-
DescriptionJPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2; inhibits cell growth in HT-29 cells with IC50 of 4.1 uM, also inhibits (14)C-leucine uptake in mouse renal proximal tubule cells expressing LAT1 and inhibits cell growth with IC50 of 0.14 and 16.4 uM, respectively; significant inhibits HT-29 tumor growth in vivo.Solid Tumors Phase 1 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsKYT-0353 | KYT0353 | KYT 0353 | JPH-203
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis
-
Research AreaCancer
-
IndicationSolid Tumors
Chemical Information
-
CAS Number1037592-40-7
-
Formula Weight472.32066
-
Molecular FormulaC23H19Cl2N3O4
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESC1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N
-
Chemical NameL-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Oda K, et al. Cancer Sci. 2010 Jan;101(1):173-9.
2. Yun DW, et al. J Pharmacol Sci. 2014;124(2):208-17.
3. Wempe MF, et al. Drug Metab Pharmacokinet. 2012;27(1):155-61.
4. Rosilio C, et al. Leukemia. 2015 Jun;29(6):1253-66.
molnova catalog
related products
-
DB2313
DB2313 is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects
-
Millepachine
Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.
-
(-)-Anonaine
(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities.
