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LY-2940094

CAS No. 1307245-86-8

LY-2940094( —— )

Catalog No. M23461 CAS No. 1307245-86-8

LY-2940094 decreases ethanol self-administration in animal models.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 180 In Stock
2MG 103 In Stock
5MG 158 In Stock
10MG 274 In Stock
25MG 542 In Stock
50MG 762 In Stock
100MG 1051 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    LY-2940094
  • Note
    Research use only, not for human use.
  • Brief Description
    LY-2940094 decreases ethanol self-administration in animal models.
  • Description
    LY-2940094 decreases ethanol self-administration in animal models. LY-2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)Dosage:3, 10, or 30 mg/kg; 2-3 mL/kg Administration:Administered orally; daily; 4 days Result:Reduced homecage ethanol self-administration.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    NOP receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1307245-86-8
  • Formula Weight
    480.96
  • Molecular Formula
    C22H23ClF2N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (86.64 mM; Need ultrasonic)
  • SMILES
    Cc(c(CN(CC1)CCC1(c(s1)c2cc1Cl)OCC2(F)F)c1)nn1-c1ncccc1CO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.
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