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LY-2940094
CAS No. 1307245-86-8
LY-2940094( —— )
Catalog No. M23461 CAS No. 1307245-86-8
LY-2940094 decreases ethanol self-administration in animal models.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 180 | In Stock |
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| 2MG | 103 | In Stock |
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| 5MG | 158 | In Stock |
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| 10MG | 274 | In Stock |
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| 25MG | 542 | In Stock |
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| 50MG | 762 | In Stock |
|
| 100MG | 1051 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY-2940094
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NoteResearch use only, not for human use.
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Brief DescriptionLY-2940094 decreases ethanol self-administration in animal models.
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DescriptionLY-2940094 decreases ethanol self-administration in animal models. LY-2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM).
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In Vitro——
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In VivoAnimal Model:Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)Dosage:3, 10, or 30 mg/kg; 2-3 mL/kg Administration:Administered orally; daily; 4 days Result:Reduced homecage ethanol self-administration.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorNOP receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1307245-86-8
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Formula Weight480.96
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Molecular FormulaC22H23ClF2N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO:41.67 mg/mL (86.64 mM; Need ultrasonic)
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SMILESCc(c(CN(CC1)CCC1(c(s1)c2cc1Cl)OCC2(F)F)c1)nn1-c1ncccc1CO
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.
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