Cart
sales@molnova.com
CU CPT 4a
CAS No. 1279713-77-7
CU CPT 4a( —— )
Catalog No. M23444 CAS No. 1279713-77-7
CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 61 | In Stock |
|
| 5MG | 104 | In Stock |
|
| 10MG | 177 | In Stock |
|
| 25MG | 376 | In Stock |
|
| 50MG | 563 | In Stock |
|
| 100MG | 800 | In Stock |
|
| 500MG | 1611 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCU CPT 4a
-
NoteResearch use only, not for human use.
-
Brief DescriptionCU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells).
-
DescriptionCU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.
-
In VitroCU-CPT 4a shows dose-dependent inhibitory effects blocking Poly (I:C)-induced TLR3 activation with an IC50 of 3.44 μM.CU-CPT 4a competes with dsRNA for binding to TLR3 with a Ki of 2.96 μM.
-
In Vivo——
-
Synonyms——
-
PathwayImmunology/Inflammation
-
TargetTLR
-
RecptorTLR3
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1279713-77-7
-
Formula Weight377.82
-
Molecular FormulaC18H13ClFNO3S
-
Purity>98% (HPLC)
-
SolubilityDMSO:<37.78mg/ml
-
SMILESO=C(O)[C@@H](CC1=CC=CC=C1)NC(C2=C(Cl)C3=CC=C(F)C=C3S2)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Cheng K , Wang X , Yin H . Small-Molecule Inhibitors of the TLR3/dsRNA Complex[J]. Journal of the American Chemical Society, 2011, 133(11):p.3764-3767.
molnova catalog
related products
-
Nelarabine
Nelarabine is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
-
CU-115
CU-115 is a selective antagonist of TLR8 with IC50s of 1.04 μM and >50 μM for TLR8 and TLR7, respectively.
-
Polyinosinic-polycyt...
Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5).
