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CU CPT 4a
CAS No. 1279713-77-7
CU CPT 4a( —— )
Catalog No. M23444 CAS No. 1279713-77-7
CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 116 | In Stock |
|
| 5MG | 105 | In Stock |
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| 10MG | 178 | In Stock |
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| 25MG | 377 | In Stock |
|
| 50MG | 551 | In Stock |
|
| 100MG | 786 | In Stock |
|
| 200MG | 1070 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCU CPT 4a
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NoteResearch use only, not for human use.
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Brief DescriptionCU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells).
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DescriptionCU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.
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In VitroCU-CPT 4a shows dose-dependent inhibitory effects blocking Poly (I:C)-induced TLR3 activation with an IC50 of 3.44 μM.CU-CPT 4a competes with dsRNA for binding to TLR3 with a Ki of 2.96 μM.
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR3
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Research Area——
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Indication——
Chemical Information
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CAS Number1279713-77-7
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Formula Weight377.82
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Molecular FormulaC18H13ClFNO3S
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Purity>98% (HPLC)
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SolubilityDMSO:<37.78mg/ml
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SMILESO=C(O)[C@@H](CC1=CC=CC=C1)NC(C2=C(Cl)C3=CC=C(F)C=C3S2)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cheng K , Wang X , Yin H . Small-Molecule Inhibitors of the TLR3/dsRNA Complex[J]. Journal of the American Chemical Society, 2011, 133(11):p.3764-3767.
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