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GSK2245035
CAS No. 1207629-49-9
GSK2245035( GSK 2245035 | GSK-2245035 )
Catalog No. M10768 CAS No. 1207629-49-9
GSK2245035 is a highly potent, selective TLR7 agonist that selectively induces TFN-α in PBMC assays with pEC50 of 9.3, >2 logs selectivity over TNFα pEC50.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 245 | Get Quote |
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| 50MG | 1107 | Get Quote |
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| 100MG | 1476 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK2245035
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NoteResearch use only, not for human use.
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Brief DescriptionGSK2245035 is a highly potent, selective TLR7 agonist that selectively induces TFN-α in PBMC assays with pEC50 of 9.3, >2 logs selectivity over TNFα pEC50.
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DescriptionGSK2245035 is a highly potent, selective TLR7 agonist that selectively induces TFN-α in PBMC assays with pEC50 of 9.3, >2 logs selectivity over TNFα pEC50; suppresses Th2 cytokine responses to allergens in human cell cultures, causes local upregulation of TLR7-mediated cytokines (IP-10) in vivo after intranasal administration at very low doses.Asthma Phase 2 Clinical.
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In Vitro——
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In VivoAnimal Model:Female BALB/c mice Dosage:0.03, 0.1, 0.3, 1 mg/kg Administration:Intranasally (i.n.); 6 hours Result:Dose-related increases in IFNα levels in serum were detected at doses of 0.3 mg/kg and above at the 2 h time point which had subsided at 6 h.
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SynonymsGSK 2245035 | GSK-2245035
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number1207629-49-9
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Formula Weight390.532
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Molecular FormulaC20H34N6O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (320.09 mM)
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SMILESCCCC(C)OC1=NC(=C2C(=N1)N(C(=O)N2)CCCCCN3CCCCC3)N
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Chemical Name(S)-6-amino-2-(pentan-2-yloxy)-9-(5-(piperidin-1-yl)pentyl)-7,9-dihydro-8H-purin-8-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Biggadike K, et al. J Med Chem. 2016 Mar 10;59(5):1711-26.
2. Ellis AK, et al. Clin Exp Allergy. 2017 Sep;47(9):1193-1203.
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