Cart
sales@molnova.com
TH1020
CAS No. 1841460-82-9
TH1020( —— )
Catalog No. M22635 CAS No. 1841460-82-9
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 37 | In Stock |
|
| 5MG | 61 | In Stock |
|
| 10MG | 92 | In Stock |
|
| 25MG | 188 | In Stock |
|
| 50MG | 346 | In Stock |
|
| 100MG | 517 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTH1020
-
NoteResearch use only, not for human use.
-
Brief DescriptionTH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
-
DescriptionTH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation. Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5. TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetAntibacterial
-
RecptorTLR5|Bacterial
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1841460-82-9
-
Formula Weight453.54
-
Molecular FormulaC23H15N7S2
-
Purity>98% (HPLC)
-
SolubilityDMSO:2 mg/mL (4.41 mM; ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 80°C)
-
SMILESC(c1ccccc1)n1c(Sc2ncnc3c4cccnc4sc23)nnc1-c1ccncc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Lei Yan, et al. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. ChemMedChem. 2016 Apr 19;11(8):822-6.
molnova catalog
related products
-
RNPA1000
RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM).
-
Etzadroxil
Etzadroxil (Ethyl 2-Ethylbutyrate) is an orally available and volatile esterification with broad-spectrum antimicrobial activity, effective in treating urinary tract infections caused by multi-drug resistant bacteria.
-
(-)-β-Pinene
(-)-β-Pinene is inhibit infectious bronchitis virus (IBV) with an IC50 of 1.32 mMwith antimicrobial activity.
