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G907

CAS No. ——

G907( G-907 | G 907 )

Catalog No. M17102 CAS No. ——

G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    G907
  • Note
    Research use only, not for human use.
  • Brief Description
    G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM.
  • Description
    G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM; traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket, inhibits the growth of wild-type E. coli and Klebsiella pneumoniae with MIC of 5.6 ug/ml.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    G-907 | G 907
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    433.932
  • Molecular Formula
    C26H24ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1
  • Chemical Name
    (E)-3-(6-(1-(2-chloro-6-cyclopropylphenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ho H, et al. Nature. 2018 May 2. doi: 10.1038/s41586-018-0083-5.
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