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VU591 hydrochloride

CAS No. 1315380-70-1

VU591 hydrochloride( —— )

Catalog No. M22454 CAS No. 1315380-70-1

VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VU591 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1.
  • Description
    VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 .
  • In Vitro
    VU591 hydrochloride is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability.
  • In Vivo
    VU591 hydrochloride (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST. Animal Model:Male ICR miceDosage:1.842 μg Administration:i.c.v.; 1.842 μg Result:Showed antidepressive effect in the tail suspension test (TST).
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Kir1.1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1315380-70-1
  • Formula Weight
    404.76
  • Molecular Formula
    C16H13ClN6O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:16 mg/mL (39.53 mM; Need ultrasonic)
  • SMILES
    Cl.[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.
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