Cart
sales@molnova.com
VU591 hydrochloride
CAS No. 1315380-70-1
VU591 hydrochloride( —— )
Catalog No. M22454 CAS No. 1315380-70-1
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 72 | In Stock |
|
| 5MG | 65 | In Stock |
|
| 10MG | 107 | In Stock |
|
| 25MG | 226 | In Stock |
|
| 50MG | 379 | In Stock |
|
| 100MG | 529 | In Stock |
|
| 200MG | 719 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameVU591 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionVU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1.
-
DescriptionVU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 .
-
In VitroVU591 hydrochloride is a selective ROMK inhibitor and a ROMK channel pore blocker. VU591 can bind serum protein and has high metabolic stability.
-
In VivoVU591 hydrochloride (i.c.v.; 1.842 μg) significantly decreases the immobile time in TST. Animal Model:Male ICR miceDosage:1.842 μg Administration:i.c.v.; 1.842 μg Result:Showed antidepressive effect in the tail suspension test (TST).
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetPotassium Channel
-
RecptorKir1.1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1315380-70-1
-
Formula Weight404.76
-
Molecular FormulaC16H13ClN6O5
-
Purity>98% (HPLC)
-
SolubilityDMSO:16 mg/mL (39.53 mM; Need ultrasonic)
-
SMILESCl.[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.
molnova catalog
related products
-
Quinine sulfate dihy...
Quinine sulfate dihydrate plays a major role in potassium channel blockers. It is also used as an antimalarial, anticholinergic, antihypertensive and a hypoglycemic agent.
-
Cromakalim
Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener and a smooth muscle relaxant.
-
AUT1
AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).
