Trigonelline hydrochloride

CAS No. 6138-41-6

Trigonelline hydrochloride( Trigonelline hydrochloride )

Catalog No. M18902 CAS No. 6138-41-6

Trigonelline hydrochloride is extracted from the seeds of Trigonellafoenum-graecumL.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
50MG 34 In Stock
100MG 47 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Trigonelline hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Trigonelline hydrochloride is extracted from the seeds of Trigonellafoenum-graecumL.
  • Description
    Trigonelline hydrochloride is extracted from the seeds of Trigonellafoenum-graecumL.(In Vitro):It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H2O2 can induce the necrosis and apoptosis along with H2O2.(In Vivo):Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Trigonelline hydrochloride
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6138-41-6
  • Formula Weight
    173.6
  • Molecular Formula
    C7H8ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 6 mg/mL 34.56 mM;
  • SMILES
    C[n+]1cccc(c1)C(=O)O.[Cl-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang DF, et al. Asian Pac J Trop Med. 2015 Aug;8(8):651-4.
molnova catalog
related products
  • NS 1619

    NS1619 have been reported to have cardio-protective effects after ischemic-reperfusion injury.

  • Pinacidil monohydrat...

    Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.Pinacidil hydrate activates the ATP-modulated potassium channels of guinea pog bladder and heart with Ki of 104 and 251 nM, respectively.

  • IK1 inhibitor PA-6

    IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1.