TKIM

Research use only, not for human use.

TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state.

TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state. Overall, identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators.

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Cell Cycle/DNA Damage

Potassium Channel

TREK-1

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326921-25-9

371.05

C18H14ClN3O2S?

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (672.33 mM)

Clc1ccc(cc1)C(=O)NNC(=O)CSc1ccc2ccccc2n1

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(-20℃)

With Ice Pack

≥ 2 years