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E-4031 dihydrochloride

CAS No. 113559-13-0

E-4031 dihydrochloride( E4031 )

Catalog No. M10476 CAS No. 113559-13-0

E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    E-4031 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr).
  • Description
    E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr), reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents.Heart Arrhythmia Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    E4031
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    113559-13-0
  • Formula Weight
    474.441
  • Molecular Formula
    C21H29Cl2N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : ≥ 50 mg/mL105.39 mM
  • SMILES
    CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.Cl.Cl
  • Chemical Name
    1-[2-(6-methyl-2pyridyl)ethyl]-4-(4-methylsulfonyl aminobenzoyl)piperidine dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Katoh H, et al. J Pharmacol Exp Ther. 1990 Jun;253(3):1077-82. 2. Sano T, et al. Br J Pharmacol. 1990 Mar;99(3):577-81. 3. Lynch JJ Jr, et al. J Cardiovasc Pharmacol. 1990 May;15(5):764-75. 4. Smith JL, et al. Am J Physiol Cell Physiol. 2013 Nov 1;305(9):C919-30.
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