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BMS-191095

CAS No. 166095-21-2

BMS-191095( —— )

Catalog No. M23744 CAS No. 166095-21-2

BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BMS-191095
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
  • Description
    BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Wistar rats with the induction of ischemia induced by middle cerebral artery occlusion (MCAO)Dosage:2.5 or 25 μg Administration:Intraventricular infusion; 30 min/60 min/24 hours before the induction of ischemia, once Result:Reduced total infarct volume in rats with of pretreat dose of 25 mg and 24 h before MCA. Induced a rapid mitochondrial depolarization.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    166095-21-2
  • Formula Weight
    408.88
  • Molecular Formula
    C22H21ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:90 mg/mL (220.11 mM)
  • SMILES
    CC(C)([C@@H]([C@H]1N(Cc2ncc[nH]2)c(cc2)ccc2Cl)O)Oc(cc2)c1cc2C#N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503.
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