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BCI

CAS No. 1245792-51-1

BCI( (E)-BCI )

Catalog No. M22447 CAS No. 1245792-51-1

BCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
5MG 114 In Stock
10MG 187 In Stock
25MG 297 In Stock
50MG 439 In Stock
100MG 619 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    BCI
  • Note
    Research use only, not for human use.
  • Brief Description
    BCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.
  • Description
    BCI is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.
  • In Vitro
    Western Blot Analysis Cell Line:RAW264.7 macrophage cells Concentration:100 ng/mL Incubation Time:24 hours Result:Showed DUSP6 protein downregulation.RT-PCR Cell Line:RAW264.7 macrophage cells Concentration:0-1 nM Incubation Time:24 hours Result:Inhibited the expression of IL-1β and IL-6 mRNA in LPS-activated macrophages.
  • In Vivo
    ——
  • Synonyms
    (E)-BCI
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1245792-51-1
  • Formula Weight
    317.42
  • Molecular Formula
    C22H23NO
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (393.80 mM; Need ultrasonic)
  • SMILES
    O=C1c2ccccc2C(NC2CCCCC2)\C1=C/c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.
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