DHODH-IN-11

Research use only, not for human use.

DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a).

DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.

Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure.

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Metabolic Enzyme/Protease

Dehydrogenase

DHODH

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1263303-95-2

265.27

C15H11N3O2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (471.22 mM)

O\N=C(/C#N)C(=O)Nc1ccc(cc1)-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years