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AKR1C1-IN-1
CAS No. 4906-68-7
AKR1C1-IN-1( —— )
Catalog No. M22361 CAS No. 4906-68-7
AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
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| 5MG | 88 | In Stock |
|
| 10MG | 147 | In Stock |
|
| 25MG | 264 | In Stock |
|
| 50MG | 430 | In Stock |
|
| 100MG | 619 | In Stock |
|
| 500MG | 1278 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAKR1C1-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionAKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).
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DescriptionAKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).
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In VitroAKR1C1-IN-1 potently inhibits the metabolism of progesterone in AKR1C1-overexpressed BAECs, and with an IC50 of 460 nM.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNADPH
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RecptorAKR1C1|AKR1C2|AKR1C3|AKR1C4
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Research Area——
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Indication——
Chemical Information
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CAS Number4906-68-7
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Formula Weight293.12
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Molecular FormulaC13H9BrO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (341.17 mM)
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SMILESO=C(C1=CC(C2=CC=CC=C2)=CC(Br)=C1O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64.
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