Cart
sales@molnova.com
AKR1C1-IN-1
CAS No. 4906-68-7
AKR1C1-IN-1( —— )
Catalog No. M22361 CAS No. 4906-68-7
AKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
|
| 5MG | 85 | In Stock |
|
| 10MG | 132 | In Stock |
|
| 25MG | 250 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 533 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAKR1C1-IN-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionAKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).
-
DescriptionAKR1C1-IN-1 is a human 20α-hydroxysteroid dehydrogenase inhibitor (AKR1C1,Ki: 4 nM).AKR1C1-IN-1 inhibits the metabolism of progesterone that in AKR1C1-overexpressed BAECs (IC50:460 nM).
-
In VitroAKR1C1-IN-1 potently inhibits the metabolism of progesterone in AKR1C1-overexpressed BAECs, and with an IC50 of 460 nM.
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetNADPH
-
RecptorAKR1C1|AKR1C2|AKR1C3|AKR1C4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number4906-68-7
-
Formula Weight293.12
-
Molecular FormulaC13H9BrO3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (341.17 mM)
-
SMILESO=C(C1=CC(C2=CC=CC=C2)=CC(Br)=C1O)O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64.
molnova catalog
related products
-
APX-115 freebase
APX-115 (Ewha 18278)?is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.
-
gp91 ds-tat
gp91 ds-tat is a NADPH oxidase (NOX2) inhibitor that reduces NOX2 expression.
-
5-Heneicosylresorcin...
5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells. 5-Heneicosylresorcinol has nematicidal activity against nematodes Panagrellus redivivus, Caenothabditis elegans and Bursaphelenchus xylophilus, with ED50 values of 80, 30, and 180 ug/mL, respectively.
