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APX-115 freebase

CAS No. 1270084-92-8

APX-115 freebase( Ewha 18278 | APX 115 | APX115 )

Catalog No. M11132 CAS No. 1270084-92-8

APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 119 In Stock
5MG 93 In Stock
10MG 155 In Stock
25MG 330 In Stock
50MG 523 In Stock
100MG 805 In Stock
200MG 1107 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    APX-115 freebase
  • Note
    Research use only, not for human use.
  • Brief Description
    APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.
  • Description
    APX-115 (Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively; shows no inhibitory activities on xanthine oxidase and glucose oxidase; inhibits the responses of BMMs to RANKL, including ROS generation, activation of MAPK and NF-κB, and osteoclast cells differentiation; protects db/db mice from renal injury.Diabetes Preclinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Six-week-old male diabetic db/db mice (C57BLKS/J-leprdb/leprdb)Dosage:60?mg/kg Administration:Oral gavage; per day; for 12 weeks Result:Significantly improved insulin resistance in diabetic mice.
  • Synonyms
    Ewha 18278 | APX 115 | APX115
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NADPH
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    1270084-92-8
  • Formula Weight
    279.343
  • Molecular Formula
    C17H17N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (894.97 mM)
  • SMILES
    ——
  • Chemical Name
    3-phenyl-1-(pyridin-2-yl)-4-propyl-1-5-hydroxypyrazol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cha JJ, et al. Lab Invest. 2017 Apr;97(4):419-431. 2. Kwon G, et al. Oncotarget. 2017 Jun 16. doi: 10.18632/oncotarget.18540. 3. Joo JH, et al. Sci Rep. 2016 Mar 15;6:22389.
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