KL1333
CAS No. 1800405-30-4
KL1333( NQO1 activator 1 )
Catalog No. M23811 CAS No. 1800405-30-4
KL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 240 | In Stock |
|
| 5MG | 182 | In Stock |
|
| 10MG | 275 | In Stock |
|
| 25MG | 497 | In Stock |
|
| 50MG | 732 | In Stock |
|
| 100MG | 995 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameKL1333
-
NoteResearch use only, not for human use.
-
Brief DescriptionKL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts.
-
DescriptionKL1333 enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
-
In Vitro——
-
In Vivo——
-
SynonymsNQO1 activator 1
-
PathwayMembrane Transporter/Ion Channel
-
TargetNADPH
-
RecptorNQO1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1800405-30-4
-
Formula Weight240.26
-
Molecular FormulaC14H12N2O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:245 mg/mL (1019.73 mM; Need ultrasonic)
-
SMILESCC(C)c1nc(-c(cccc2)c2C(C2=O)=O)c2[nH]1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018 Jul 5;9:552.
molnova catalog
related products
-
Phox-I2
Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.
-
GKT137831
GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM.
-
GKT136901
GKT136901 is an ?inhibitor of NOX1/4.It acts?as Selective and Direct Scavenger of Peroxynitrite.
Cart
sales@molnova.com