Tafluprost

Research use only, not for human use.

Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.Tafluprost showed significant IOP-lowering effects without any safety concerns in patients with various types of glaucoma and OH in daily clinical practice and tafluprost is highly effective in any therapeutic pattern.

Tafluprost, a prostaglandin analog, is the selective agonist of fluoroprostaglandin (FP) receptor PGF2α.Tafluprost showed significant IOP-lowering effects without any safety concerns in patients with various types of glaucoma and OH in daily clinical practice and tafluprost is highly effective in any therapeutic pattern. Tafluprost with reduced BAK has potential as a superior antiglaucoma drug, not only for its IOP-lowering effect but also for its good corneal safety profile. Tafluprost single-use vials treatment was effective in reducing IOP over the 3 years of this study, but visual field performance worsened by 10.3%-13.8% in patients with normal-tension glaucoma.

Cell Viability Assay Cell Line:RGC Concentration:0.1, 1, 3, 10, 100 μM Incubation Time:48 h Result:Enhanced the viability of these cells in a dose-dependent fashion, with an optimal concentration of 3μM.Increased the relative fluorescence intensity (RFI).

Animal Model:Male Sprague rat model Dosage:0.0015% Administration:Via eye drops Result:Increased the number of RGCs and reduced the number of TUNEL-positive cells.Animal Model:Prostaglandin receptor deletion C57BL/6 mice model Dosage:3 μL (0.0015% Tafluprost)Administration:Instillation; Single dose Result:Reduced IOP in WT, EP1KO, EP2KO, EP3KO and FPKO mice, and the average IOP reduction rates were 25.8(2.1)%, 26.3(0.8)%, 24.2(1.4)%, 16.5(1.7)% and 20.9(1.5)%, respectively. (The decrease of IOP in EP3KO and FPKO mice was less than that in WT mice.)

AFP-168,MK2452

GPCR/G Protein

Prostaglandin Receptor

PGF2α

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209860-87-7

452.53

C25H34F2O5

>98% (HPLC)

DMSO:250 mg/mL (552.45 mM)

CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(F)(F)COc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years