GW 627368X( GW627368X | GW 627368X | GW-627368X | GW627368 )

Catalog No. M14493 CAS No. 439288-66-1

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Product Name

GW 627368X
Note

Research use only, not for human use.
Brief Description

GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).
Description

GW627368(GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).
In Vitro

——
In Vivo

Animal Model:6-8 weeks Swiss albino mice Dosage:0 mg/kg, 5 mg/kg, 10 mg/kg, 15 mg/kg, 15 mg/kg Administration:Oral administration, every alternate day for 28 days Result:Displayed anti-tumor and anti-proliferative potential in sarcoma 180 bearing mice.
Synonyms

GW627368X | GW 627368X | GW-627368X | GW627368
Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

EP4
Research Area

Inflammation/Immunology
Indication

——

CAS Number

439288-66-1
Formula Weight

544.62
Molecular Formula

C30H28N2O6S
Purity

>98% (HPLC)
Solubility

DMSO: 10 mg/mL
SMILES

O=C(NS(=O)(C1=CC=CC=C1)=O)CC2=CC=C(N(CC3=C4C(OCC)=C(C=CC=C5)C5=C3OCC)C4=O)C=C2
Chemical Name

2-(4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl)-N-(phenylsulfonyl)acetamide

1.Wilson RJ, et al. Br J Pharmacol. 2006 Jun; 148(3): 326-39.

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