TG6-129( TG6 129 | TG6129 )

Catalog No. M27930 CAS No. 1164464-14-5

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

TG6-129
Note

Research use only, not for human use.
Brief Description

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM.
Description

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages.
In Vitro

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In Vivo

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Synonyms

TG6 129 | TG6129
Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

estrogen receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1164464-14-5
Formula Weight

491.57
Molecular Formula

C20H18FN5O3S3
Purity

>98% (HPLC)
Solubility

——
SMILES

CCc1nnc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)\C=C\c3ccc(F)cc3)cc2)s1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368.

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