TG6-129( TG6 129 | TG6129 )

Catalog No. M27930 CAS No. 1164464-14-5

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	339	In Stock
5MG	240	In Stock
10MG	427	In Stock
25MG	702	In Stock
50MG	918	In Stock
100MG	1293	In Stock
200MG	Get Quote	In Stock
500MG	2623	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

TG6-129
Note

Research use only, not for human use.
Brief Description

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM.
Description

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages.
In Vitro

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In Vivo

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Synonyms

TG6 129 | TG6129
Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

estrogen receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1164464-14-5
Formula Weight

491.57
Molecular Formula

C20H18FN5O3S3
Purity

>98% (HPLC)
Solubility

——
SMILES

CCc1nnc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)\C=C\c3ccc(F)cc3)cc2)s1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368.

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