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FPTQ
CAS No. 1025802-62-3
FPTQ( —— )
Catalog No. M22082 CAS No. 1025802-62-3
FPTQ is an antagonist of mGluR1.FPTQ is a synthetic isoquinoline derivative.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 357 | In Stock |
|
| 10MG | 597 | In Stock |
|
| 25MG | 882 | In Stock |
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| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFPTQ
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NoteResearch use only, not for human use.
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Brief DescriptionFPTQ is an antagonist of mGluR1.FPTQ is a synthetic isoquinoline derivative.
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DescriptionFPTQ is an antagonist of mGluR1.FPTQ is a synthetic isoquinoline derivative.Neutrophils translocation in the zebrafish tail-transected model was inhibited by FPTQ. Neutrophil aggregation was also inhibited by FPTQ in the LPS-stimulated zebrafish model. Decreased mRNA expression of the pro-inflammatory cytokine genes, interleukin-1β (il-1β) and interleukin-6 (il-6), was found in zebrafish larvae injected with FPTQ. Additionally, production of nitric oxide was inhibited by FPTQ in RAW264.7 macrophage cells treated with LPS. Moreover, the mRNA expression of Il-1β and Il-6 suppressed by FPTQ treatment in RAW264.7 macrophage cells, and an enzyme immunoassay showed that FPTQ suppressed the secretion of IL-1β and IL-6 in RAW264.7 cells. These results demonstrate that FPTQ reduced inflammatory responses and, therefore, suggest that it may be effective as an anti-inflammatory agent.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptormGluR1
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Research Area——
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Indication——
Chemical Information
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CAS Number1025802-62-3
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Formula Weight305.32
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Molecular FormulaC17H12FN5
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Purity>98% (HPLC)
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Solubility——
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SMILESCc1c(nnn1-c1cccnc1F)-c1ccc2cccnc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Geum Ran Kim, Jung Yoon Yang, Kyu-Seok Hwang,et al. Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl)thio)isoquinoline in RAW264.7 macrophages and a zebrafish model.[J]. Fish & shellfish immunology, 2019.
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