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BI-3406
CAS No. 2230836-55-0
BI-3406( —— )
Catalog No. M21998 CAS No. 2230836-55-0
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
|
| 5MG | 155 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 464 | In Stock |
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| 50MG | 649 | In Stock |
|
| 100MG | 900 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1795 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBI-3406
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NoteResearch use only, not for human use.
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Brief DescriptionBI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
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DescriptionBI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorKRAS-SOS1|MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number2230836-55-0
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Formula Weight462.46
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Molecular FormulaC23H25F3N4O3
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Purity>98% (HPLC)
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SolubilityDMSO:95mg/ml (205.42 Mm; Need ultrasonic);Ethanol:100 mg/mL (216.23 mM; Need ultrasonic
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SMILESCOC1=C(O[C@H]2CCOC2)C=C2C(N[C@H](C)C3=CC(=CC(N)=C3)C(F)(F)F)=NC(C)=NC2=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.2. Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.
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