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Home - Products - MAPK/ERK Signaling - Ras - BI-3406

BI-3406

CAS No. 2230836-55-0

BI-3406( —— )

Catalog No. M21998 CAS No. 2230836-55-0

BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 169 In Stock
5MG 155 In Stock
10MG 250 In Stock
25MG 464 In Stock
50MG 649 In Stock
100MG 900 In Stock
200MG Get Quote In Stock
500MG 1795 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    BI-3406
  • Note
    Research use only, not for human use.
  • Brief Description
    BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
  • Description
    BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    KRAS-SOS1|MAPK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2230836-55-0
  • Formula Weight
    462.46
  • Molecular Formula
    C23H25F3N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:95mg/ml (205.42 Mm; Need ultrasonic);Ethanol:100 mg/mL (216.23 mM; Need ultrasonic
  • SMILES
    COC1=C(O[C@H]2CCOC2)C=C2C(N[C@H](C)C3=CC(=CC(N)=C3)C(F)(F)F)=NC(C)=NC2=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.2. Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.
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