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ARS-1323

CAS No. 1698024-73-5

ARS-1323( ARS1323 )

Catalog No. M12590 CAS No. 1698024-73-5

ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 57 In Stock
2MG 32 In Stock
5MG 51 In Stock
10MG 86 In Stock
25MG 131 In Stock
50MG 167 In Stock
100MG 243 In Stock
200MG 362 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    ARS-1323
  • Note
    Research use only, not for human use.
  • Brief Description
    ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor.
  • Description
    ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with >10-fold improved potency over the initial ARS-853.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ARS1323
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    Ras
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1698024-73-5
  • Formula Weight
    430.84
  • Molecular Formula
    C21H17ClF2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 290.13 mM
  • SMILES
    C=CC(=O)N1CCN(CC1)C2=NC=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC=C4F)O)F
  • Chemical Name
    1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Janes MR, et al. Cell. 2018 Jan 25;172(3):578-589.e17.
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