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Sotorasib
CAS No. 2252403-56-6
Sotorasib( AMG-510 racemate )
Catalog No. M21832 CAS No. 2252403-56-6
Sotorasib (AMG-510) racemate is the racemate of Sotorasib (AMG-510). AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 73 | In Stock |
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| 25MG | 150 | In Stock |
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| 50MG | 268 | In Stock |
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| 100MG | 418 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 918 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSotorasib
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NoteResearch use only, not for human use.
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Brief DescriptionSotorasib (AMG-510) racemate is the racemate of Sotorasib (AMG-510). AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
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DescriptionSotorasib (AMG-510) racemate is the racemate of Sotorasib (AMG-510). AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
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In Vitro——
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In VivoAnimal Model:Female NOD/SCID mice, tumor xenograft model of NCI-H358 cells which harbor KRAS G12C (human NSCLC cell)Dosage:10, 30, 100 mg/kg Administration:Oral gavage (p.o.), QD for 21 d Result:Suppressed the growth of the NCI-H358 tumors in a dose-dependent manner, observed significant tumor regression at 100 mg/kg and 30 mg/kg with tumor growth inhibition of 137% and 126%, respectively.
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SynonymsAMG-510 racemate
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PathwayMAPK/ERK Signaling
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TargetRas
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2252403-56-6
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Formula Weight560.59
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Molecular FormulaC??H??F?N?O?
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Purity>98% (HPLC)
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SolubilityDMSO : 3.85 mg/mL (6.87 mM; Need ultrasonic)
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Karen Rex, et al. Abstract 3090: In vivo characterization of AMG 510 - a potent and selective KRASG12Ccovalent small molecule inhibitor in preclinical KRASG12Ccancer models. Experimental and Molecular Therapeutics.
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