Deltasonamide 2( Deltasonamide2 )

Catalog No. M13258 CAS No. 2088485-34-9

COA

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HNMR

HPLC

MSDS

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Product Name

Deltasonamide 2
Note

Research use only, not for human use.
Brief Description

Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM.
Description

Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM; inhibits PDE6δ/KRas interaction in cells with Kd of 64 nM, selectively inhibits growth of KRas mutated and -dependent cells, inhibits the oncogenic KRas-dependent MiaPaCa-2 with IC50 of 750 nM.
In Vitro

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In Vivo

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Synonyms

Deltasonamide2
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

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Indication

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CAS Number

2088485-34-9
Formula Weight

647.25
Molecular Formula

C30H39ClN6O4S2
Purity

>98% (HPLC)
Solubility

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SMILES

O=S(C1=CC=C(S(=O)(N(CC2=CC=C(Cl)C=C2)C3CCCC3)=O)C=C1)(N([C@H]4CC[C@H](N)CC4)CC5=NC(NC)=NC=C5)=O
Chemical Name

N1-((1r,4r)-4-aminocyclohexyl)-N4-(4-chlorobenzyl)-N4-cyclopentyl-N1-((2-(methylamino)pyrimidin-4-yl)methyl)benzene-1,4-disulfonamide

1. Martín-Gago P, et al. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428.

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