ASP2453( —— )

Catalog No. M28235 CAS No. 2241719-73-1

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC 50 value of 40 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	434	In Stock
5MG	282	In Stock
10MG	426	In Stock
25MG	661	In Stock
50MG	870	In Stock
100MG	Get Quote	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

ASP2453
Note

Research use only, not for human use.
Brief Description

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC 50 value of 40 nM.
Description

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC 50 value of 40 nM.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

——
Research Area

——
Indication

——

Chemical Information

CAS Number

2241719-73-1
Formula Weight

747.85
Molecular Formula

C40H48F3N7O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (334.29 mM)
SMILES

Cc(ccc1c2cn[nH]1)c2-c(c(C1CC1)cc(c1n2)c(N3CCC(C4)(CN4C(C=C)=O)CC3)nc2OC2CCN(CCCOC)CC2)c1OCC(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Abdolreza Hassanzadeh, et al. Mechanism for the degradation of erythromycin A and erythromycin A 2'-ethyl succinate in acidic aqueous solution. J Phys Chem A. 2007 Oct 11;111(40):10098-104.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks