ARS-1323-alkyne( —— )

Catalog No. M24120 CAS No. 2436544-27-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ARS-1323-alkyne
Note

Research use only, not for human use.
Brief Description

ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
Description

ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

KRAS G12C
Research Area

——
Indication

——

CAS Number

2436544-27-1
Formula Weight

569
Molecular Formula

C28H27ClF2N6O3
Purity

>98% (HPLC)
Solubility

DMSO:35.71 mg/mL (62.76 mM; Need ultrasonic)
SMILES

O=C(C=C)N1CCN(C2=NC(NCCC(N(C)CC#C)=O)=NC3=C(F)C(C4=C(O)C=CC=C4F)=C(Cl)C=C23)CC1
Chemical Name

——

1.Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.

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