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LC3-mHTT-IN-AN1
CAS No. 486443-73-6
LC3-mHTT-IN-AN1 ( —— )
Catalog No. M21755 CAS No. 486443-73-6
LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 274 | In Stock |
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| 50MG | 445 | In Stock |
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| 100MG | 714 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLC3-mHTT-IN-AN1
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NoteResearch use only, not for human use.
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Brief DescriptionLC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.
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DescriptionLC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
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In VitroLC3-mHTT-IN-AN1 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons.
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number486443-73-6
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Formula Weight411.04
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Molecular FormulaC??H?Br?NO?
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Purity>98% (HPLC)
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SolubilityDMSO : 125 mg/mL (304.11 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)
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SMILESBrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.
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