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Vonafexor
CAS No. 1192171-69-9
Vonafexor( EYP001 )
Catalog No. M21752 CAS No. 1192171-69-9
Vonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 42 | In Stock |
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| 25MG | 88 | In Stock |
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| 50MG | 137 | In Stock |
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| 100MG | 230 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVonafexor
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NoteResearch use only, not for human use.
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Brief DescriptionVonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.
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DescriptionVonafexor (EYP001) is a selective FXR agonist with anti-HBV effects.(In Vitro):Vonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910).
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In VitroVonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910).
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In Vivo——
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SynonymsEYP001
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PathwayMetabolic Enzyme/Protease
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TargetFXR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1192171-69-9
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Formula Weight489.76
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Molecular FormulaC??H??Cl?N?O?S
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Purity>98% (HPLC)
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SolubilityDMSO : 83.33 mg/mL (170.14 mM; Need ultrasonic)
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SMILESO=C(C1=CC2=C(Cl)C(N3CCN(S(=O)(C4=C(Cl)C=CC=C4Cl)=O)CC3)=CC=C2O1)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Joly S, et al. The selective FXR agonist EYP001 is well tolerated in healthy subjects and has additive anti-HBV effect with nucleoside analogues in HepaRG cells. J Hepatol 66(1):S690.
2. Fiorucci S,et al. Bile acid modulators for the treatment of nonalcoholic steatohepatitis (NASH) [published online ahead of print, 2020 Jun 19]. Expert Opin Investig Drugs. 2020;1-10.
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