GSK-2324( GSK2324 | GSK 2324 )

Catalog No. M10099 CAS No. 1020567-30-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK-2324
Note

Research use only, not for human use.
Brief Description

GSK-2324 (GSK2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay.
Description

GSK-2324 (GSK2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay; lowers body weight gain and serum glucose in a DIO mouse model of diabetes.
In Vitro

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In Vivo

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Synonyms

GSK2324 | GSK 2324
Pathway

Metabolic Enzyme/Protease
Target

FXR
Recptor

FXR
Research Area

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Indication

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CAS Number

1020567-30-9
Formula Weight

533.405
Molecular Formula

C29H22Cl2N2O4
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC=C(C=C3)C4=CC5=C(C=C4)N=C(C=C5)C(=O)O
Chemical Name

6-(4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)phenyl)quinoline-2-carboxylic acid

1. Bass JY, et al. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13. 2. de Aguiar Vallim TQ, et al. Circ Res. 2013 Jun 7;112(12):1602-12.

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