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MMP-9-IN-1
CAS No. 502887-71-0
MMP-9-IN-1( —— )
Catalog No. M21587 CAS No. 502887-71-0
MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 120 | In Stock |
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| 2MG | 65 | In Stock |
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| 5MG | 107 | In Stock |
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| 10MG | 170 | In Stock |
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| 25MG | 345 | In Stock |
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| 50MG | 514 | In Stock |
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| 100MG | 732 | In Stock |
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| 200MG | 995 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMMP-9-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionMMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).
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DescriptionMMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).
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In VitroMMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity.MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells. Cell Cytotoxicity Assay Cell Line:COS-1 monkey epithelial cell lines Concentration:100 μM Incubation Time:24 hours Result:Treatment did not cause notable cytotoxicity. Cell Proliferation Assay Cell Line:HT-1080 and MDA-MB-435 cancer cells expressing endogenous MMP-9Concentration:10 μM Incubation Time:9 days Result:Significant inhibition of cell proliferation.
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In VivoMMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor. MMP-9-IN-1 inhibits cancer cell metastasis in vivo. Animal Model:4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumorDosage:20 mg/kg Administration:Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks,Result:Resulted in a profound delay in tumor growth.Inhibited cancer cell metastasis.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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RecptorMMP-9
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Research Area——
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Indication——
Chemical Information
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CAS Number502887-71-0
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Formula Weight369.39
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Molecular FormulaC16H17F2N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (338.40 mM; Need ultrasonic)
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SMILESCCCc1cc(=O)[nH]c(SCC(=O)Nc2ccc(OC(F)F)cc2)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dufour A et al. Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9. Cancer Res. 2011 Jul 15;71(14):4977-88.
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