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CL-82198
CAS No. 307002-71-7
CL-82198( —— )
Catalog No. M24236 CAS No. 307002-71-7
CL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 64 | In Stock |
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| 25MG | 147 | In Stock |
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| 50MG | 237 | In Stock |
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| 100MG | 369 | In Stock |
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| 200MG | 541 | In Stock |
|
| 500MG | 849 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCL-82198
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NoteResearch use only, not for human use.
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Brief DescriptionCL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression.
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DescriptionCL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs.
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In Vitro——
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In VivoAnimal Model:10-week-old C57BL/6J mice (performed MLI surgery)Dosage:1, 5, 10 mg/kg body weight Administration:Intraperitoneal injection; every other day for 12 weeks Result:Prevented and decelerated MLI-induced osteoarthritis progression.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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RecptorMMP-13
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Research Area——
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Indication——
Chemical Information
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CAS Number307002-71-7
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Formula Weight302.37
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Molecular FormulaC17H22N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (330.72 mM; Need ultrasonic)
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SMILESO=C(c1cc(cccc2)c2o1)NCCCCN1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488.
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