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Home - Products - Metabolic Enzyme/Protease - MMP - CL-82198

CL-82198

CAS No. 307002-71-7

CL-82198( —— )

Catalog No. M24236 CAS No. 307002-71-7

CL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 35 In Stock
10MG 60 In Stock
25MG 140 In Stock
50MG 230 In Stock
100MG 357 In Stock
200MG 524 In Stock
500MG 822 In Stock
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Biological Information

  • Product Name
    CL-82198
  • Note
    Research use only, not for human use.
  • Brief Description
    CL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression.
  • Description
    CL-82198 is a selective inhibitor of MMP-13 and it is a pharmacologic treatment for preventing osteoarthritis (OA) progression. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs.
  • In Vitro
    ——
  • In Vivo
    Animal Model:10-week-old C57BL/6J mice (performed MLI surgery)Dosage:1, 5, 10 mg/kg body weight Administration:Intraperitoneal injection; every other day for 12 weeks Result:Prevented and decelerated MLI-induced osteoarthritis progression.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    MMP
  • Recptor
    MMP-13
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    307002-71-7
  • Formula Weight
    302.37
  • Molecular Formula
    C17H22N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (330.72 mM; Need ultrasonic)
  • SMILES
    O=C(c1cc(cccc2)c2o1)NCCCCN1CCOCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488.
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